Abstract: Objective To investigate connective tissue growth factor(CTGF),cyste in-rich 61(Cyr61)expression levels and their correlative factors in human esophagus carcinomas.Methods We quantified CTGF,Cyr61 expression levels in 186 esophageal cancer tissues and normale sophagus tissues around the tumor with real-time PCR assay and mimunoh istochemistry staining and analyzed correlative factors by logistic regression.Results Compared with normal esophagus tissue,sup-regulations of CTGF,Cyr61 mRNA(5.29?5.12,7.13?4.26)were found in esophageal cancer tissues (P=0.000).The CTGF,Cyr61 protein expression levels of esophageal cancer tissues(20.83?8.20,16.79?6.81)were significantly higher than that of in the normal esophagus tissues(P=0.000).Multiple factor logistic regression showed that in esophageal cancer,smoking and infiltrating depth were the risk factors of CTGF mRNA expression(P<0.01).Smoking,metastasis,family history,tumorsize and tumorstage were the risk factors of CTGF protein expression(P<0.05).Metastasis,tumorsize and infiltrating depth were the risk factors of Cyr61 mRNA expression(P<0.05).Metastasis,tumor stage and infiltrating depth were the risk factors of Cyr61 protein expression(P=0.001).Conclusion CTGF,Cyr61 may play a role in the progression of esophageal cancer,and may be an important target for gene therapy.