Abstract: Objective To study the effects of passive smoking on growth,growth hormone(GH),estradial(E2);cholesterol, blood glucose,organs quality,and mimune function in mice.Methods Thirty-six Wistar rats(18 male)were randomly devided into control group,low and high dose passive smoking group.The passive smoking groups were exposed to smoke for 35 days.The body weight was measured before and after the expermient.The cholesterol,blood glucose,IL 10,IFN-C,TN F-A,GH,and E2 were detected.The heart,liverspleen,kidney,lung,and brain of the mice were weighted.Results The body weight of the mice in high dose passive smoking group increased significantly compared to other groups (P<0.05).E2 of low and high dose passive smoking group was significantly different from that of the control group.But no difference was found between low and high dose passive smoking groups.Cholesterol in high dose group was significantly higher than that of the control group.But blood glucose,GH and organs weight showed no obvious difference among the three groups(P>0.05).Conclusion High dose passive smoking could affect the growth and induce abnormal lipid methabo lism in rats.