Abstract: ObjectiveTo understand the geographical landscape structure of epidemic area of hemorrhagic fever with renal syndrome(HFRS)and to analysis the characteristics of the epidemic in order to provide a theoretical basis for preventive measures of the disease.MethodsAccording to data of HFR Sepidemic,14 areas were chosen and the investigation was carried out with an application of geographical landscape and seroepidemio logical survey to analyze the epidemic characteristic of the disease.ResultsThe local landscape characteristic was maily hills and plains with subtropical and temperate climate and the environment provided a favourable condition for the host animal of HFRS.Apodemus agrarius and Rattus norvegicus were principal animal reservoir of HFRS.Among 4386 murine animals screend,267(5.1%)were HFRS antigen positive and 364(8.3%)were HFR Santibody positive.The incidence rate of HFRS increased in the latest five years compared with that of in the year 2000.ConclusionThe southeast coastal area is still an important hem rrhagic fever epidemic area and further detection and analysis a rerequired.