Abstract: ObjectiveTo explore the expression of phospha tidy linositol 3-kinase(PI3Ks)in cortical neuron of mice with chronic lead exposure.MethodsAcetic lead(1.2,2.4,4.8,7.2,and 9.6 mmol/L)in drinking water was applied to mice for 6 weeks.At the end of the exposure,blood lead concentration and brain lead concentration in the mice were detemined with graphite furnace a tomic absorption spectrometry and the expression of PI3Ks was determined with Western blotting.ResultsCompared with the control group,the expression of PI3Ks in cortical neuron of lead exposure group was decreased in significant dose-dependent manner(P<0.05).The expression of PI3Ks in cortical neuron was negatively correlated with the concentration of blood lead and brain lead(r=-0.82,P<0.01).ConclusionChronicacetic lead exposure can depress the expression of PI3Ks in mice which is maybe one of the reasons for lead-induced damage of learning and memory.