Abstract: ObjectiveTo compare the levels of blood nickel(Ni),chromium(Cr)and related metal elements between patients with Ni-Cr based porcelain-fuse-metal crown treatment and general population.MethodsOrerall 91 patients treated with Ni-Cr based porcelain-fuse-metal crown were selected as cases,and 63 healthy males were selected as control group.Vein blood were collected before breakfast.Blood samples were digested with microwave digestive system.Levels of Ni, Cr and related metale lements in the blood were determined with ICP-MS.ResultsThe levels of Ni and Cr of the patients with Ni-Cr based porce lain-fuse-metal crown were 9.2±6.0 ng/mL and 1.7±2.0 ng/mL,respectively.The level of Ni was significantly different from that of in general population(P<0.05).The levels of blood Sr,Cs and Co among the patients were 40.0±15.0,4.6±1.2,and 1.0±0.7 ng/mL,respectively,and were significantly different from that of general population (P<0.05).ConclusionNi-Cr based porcela in-fuse-metal crown may affect the levels of blood mental elements in human.