Abstract: Objective To observe the systemic inflammatory changes of blood,endo the lial damages,and cardiov ascular effects caused by PM₁₀.Methods Thirty twomale Wistar ratsw eighted 380-470g were randomly divided into one control group and three PM₁₀ exposed groups.PM₁₀ were administered to the rats by intra tracheal in stillation at the doses of 5,15,45m g/kg·bw,respectively.The rats were sacr ificed 24 hours a fter the treamtent.The number of blood cells and the levels of IL-6,TNF-α,hypersensitive Creactive prote in(hs-CRP),nitricoxide and Von Willebrand factor in the serum were deter mined.Results The number of white blood cells,the percentage of neutrophils,the levels of IL-6,and hs-CRP in the serum increased significantly in all the PM₁₀ treated rats.TNF-α level in the serum increased markedly in 15 and 45mg/kg PM₁₀ treated rats.No significant change was found in the levels of nitricoxide and Von Willebrand factor in the serum of PM₁₀ treated rats.Conclusion The study showed that PM₁₀ can cause systemic inflammation.However,there is no significant change in the blood indices for endothelial injury.