Abstract: Objective To study the irlfluence of apolipopmtein E(ApoeE)ε2 allele gene on metaboli; disease in Uygurel)lnioity.Methods Thebbod sanples of 386 subjects aged 20 to 70 years wele colled from January to December 2006 in Urum chi.The subjects were detected for hight,weiht waist circum ference,abdomen circum ference,glycer in(GLU),serum trigly ceride(TG),serum total cholesterol(TC),serm high density lipoprote in cholesterol(HDL C),and serum lowdensity lipoprote in chole sterol(LD LC).A polipo prete in E gene polymor phism was de termined with polymerized chainreaction restriction fragment length polymorphism(PCR RFLP).Results The frequence of Apoe ε2 allele gene in Uygur people was 31.9%(123/386).Compared with the non ε2 a llele group,normal health and blood biochemistry markers of lipid metabo lism decreased in people with ε2 allele gene.The systo lic blood pressure,diastolic blood pressure and LDL C showed sign ificant difference(P<0.05)and the prelevance of metabolic diseases decreased,especially for hyperchole sterem ia and hypertension among the subjects with Apo ε2 allele gene.Conclusion The ε2 allele gene of apolipopretein E genecan decrease the pre levance of metabolic disease,and may be a protective factor of metabolic disease in Uygur ethnicity.