Abstract: Objective To study the hypoglycemic effect of housefly maggot chitosan(HM C)in normal and diabetic mice.Methods HMC was orally administered to normal and diabetic mice for 20 days.The diabetic model in mice were established with a lloxan in jection in venacauda lis.Blood glucose was measured at different time.Results In nomal mice,there was no significant difference in the level of blood glucose between HMC treatment group and control group.In diabetic mice,the blood glucose level of HM C treatment guoup was significantly lower than that of model group(P<0.01).The blood glucose at 0,0.5,2 hr and glucose tolerance of the mice in treatment group were significantly lower than that of model guoup(P<0.05,P<0.01).Conclusion HMC has no effect on blood glucose in norm al mice.But HMC could decrease the blood glucose and glucose to lerance significantly in diabetic mice.