党参硒多糖对微血管反应性及抗氧化酶影响

谭志鑫; 肖本见; 廖艳华

doi:10.11847/zgggws2010-26-05-26

党参硒多糖对微血管反应性及抗氧化酶影响

Effects of Se-polysaccharides in Codonopsis pilosula on microvessel response and anti-oxidation enzyme in rats

摘要

摘要: 目的探讨党参硒多糖对急性低氧条件下肠系膜微动脉血管反应性和抗氧化酶的影响。方法 SD大鼠用党参硒多糖处理后,造成低氧,观察肠系膜微动脉血管口径、血流速度和血浆中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和活性氧(ROS)含量的变化。结果治疗组与对照组比较,肠系膜微动脉血管口径变化不大,而血液流速增快,在低氧10,15,20,25 min时分别为(3.27±0.81),(2.97±0.67),(2.74±0.62)mm/s(P<0.01,P<0.05);ROS明显减少为(575.00±14.63)u/mL(P<0.01),SOD、CAT和GSH-Px活力明显增加,分别为(185.11±13.92)Nu/mL,(75.76±3.22)u/mL,(27.85±3.01)u/mL(P<0.01)。结论急性低氧可使肠系膜微动脉管径变大和血细胞流速减慢,同时体内抗氧化酶活性减弱;而党参硒多糖能增加血细胞流速,提高抗氧化酶活性。

Abstract: Objective To study the effects of Se-polysaccharides in Codonopsis pilosula on mesentery microvessel response and anti-oxidation enzyme in rats with acute hypoxia.Methods SD Rats were treated with Se-polysaccharides in Codonops is pilosula and then exposed to hypoxia.The diameter of the microvessel,speed of bloods tream,the activities of supe roxide dismutase(SOD),glutathione peroxidase(GSH-Px),catalase(CAT),and the content of reactive oxygen(ROS) in plasma of the rats were measured.Results Compared with the control group,the speed of the bloods tream became fast gradually(3.27±0.81,2.97±0.67,2.74±0.62 mm/s at 10,15,25 minutes after hypoxia;P<0.01,P<0.05).The content of ROS went downs lightly(575.00±14.63 u/mL,P<0.01).The activities of SOD,CAT and GSH-Px were increased (185.11±13.92 Nu/mL,75.76±3.22 u/mL,27.85±3.01 u/mL,P<0.01).Conclusion Acute hypoxia could enlarge mesentery microvessels,slow the speed of blood stream and decrease the avtivity of anti-oxidation enzyme.Se-polysaccharides in Codonopsis pilosula could increase the speed of bloods tream and the avtivity of anti-oxidation enzyme.

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