Abstract: Objective To investigate mental health status and its influencing factors in farmers losing farmland with multi-level model and logistic regression model.Methods Farmers losing farmland in two communities of Xuzhou city were randomly selected with stratified cluster sampling method and the data collected with qnestionnaire survey were analyzed with multi-level model and logistic regression mode.Results The majority of the farmers losing farmland were young women(<65 years:82.0%,women:63.4%)and with less education(under junior middle school:73.3%).Without commercial insurance(OR=3.073),with chronic disease(OR=2.414),less help from family members(OR=2.003),elder age(OR=1.818),and without endowment insurance(OR=1.664)were risk factors for mental health of the farmers.Playing cards(OR=0.688)and without medical insurance(OR=0.532)were the protective factors of mental health with logistics model.With chronic disease(OR=3.518),without commercial insurance(OR=3.016),and less help from family members(OR=2.022)were the risk factor and wtihout medical insurance(OR=0.614),at age of≥65 years (OR=0.506)were the protective factors when multi-level model was adopted.Conclusion The improvement of social security system and medical system can promote mental health in farmers losing farmland.