Abstract: ObjectiveTo investigate the prevalence and distribution of major depression disorders among people aged ≥15 years in urban and rural areas of Guangxi Zhuang Autonomous Region.MethodsFrom July through December, 2007,21 290 subjects aged≥15 years were randomly selected with stratified multi-stage cluster sampling method.All subjects were investigated with a face-to-face interview.The Composite International Diagnostic Interview(CIDI 3.0)was used as the screening tool and the diagnoses were made with the 10th edition of International Classfication of Disease Criteria.ResultsThe current prevalence of major depression disorders was 4.32‰ in the female and 2.50‰ in the male with a significant difference(P<0.05).The lifetime prevalence of major depression disorders was 5.98‰ in the female and 4.68‰ in the male.The lifetime prevalence of major depression disorders was different in adullts of different age(P<0.05).There was a statistically significant difference(P<0.05)in the current prevalence of major depression disorders between different age groups with a current prevalence peaks in the adults at age of 55-64 years.There were differences in the current and lifetime prevalence of major depression between adults with different marital status(P<0.05)with higher current and lifetime prevalences among the adults divorced.ConclusionMajor depression disorder is prevalent among urban and rural adult residents in Guangxi and correlates to some socio-demographic factors.