Abstract: Objective To investigate the prevalence of cervical intraepithelial neoplasia (CIN) and its influencing factors among rural minority married women in Guizhou province for providing reference of CIN diagnostic criteria.Methods From December 2009 to 2010,3 968 married women at age of 18 to 55 years were selected randomly for a cross sectional survey in 40 villages of Qiannan area of Guizhou province.The survey was carried out with a unified questionnaire interview and gynecological examination.The cervical smear cytology and high-risk human papillomavirus(HR-HPV) infection of cervical secretion were detected.Women with abnormal cervical cytology underwent colposcopy and cervical biopsy.Odd ratio(OR) and 95% confidence interval(95% CI) of related risk factors with CIN were calculated with logistic regression.Results Among the women,12.02% had abnormal cytological result.The colposcopy and cervical biopsy show ed a CIN rate of 9.35% in all women selected and the rate was 77.78% in the women with abnormal cervical cytology.The rate of cervical lesions was 5.89% in Shui women,1.49% in Maonan women,1.18% in Buyi women,and 0.78% in Miao women (P< 0.01).The multinomial regression analyses showed that HR-HPV infection,history of trichomonas vaginitis,oral contraceptives,age less than 40 years old,smoking,number of sex partners ≥2,age of first intercourse ≤18 years,and nationality were related to CIN.Conclusion The prevalence rate of CIN in the monority area was high.The propaganda and education on know ledge of prevention and control of CIN should be strengthened in the rural area.