Abstract: Objective To evaluate the significance of risk factors in the diagnosis of coronary heart disease(CHD) in patients underw ent coronary angiography.Methods A total of 812 patients underwent coronary angiography were selected according to the inclusion criteria in Qilu Hospital from October 2008 to December 2009.Cardiovascular risk factors included age,gender,hypertension,smoking status,type 2 diabetes mellitus,dyslipidemia,high uric acid level,and low total bilirubin level.The sensitivity and specificity of the cardiovascular risk factors for diagnosis of CHD were analyzed.Analyses were aconducted with multiple logistic regression analysis.Results Gender,age,low high-density lipoprotein cholesterol (HDL-C) level,hypertension,and type 2 diabetes mellitus were significant predictors of CHD by logistic regression analyses,with a sensitivity of 95.47% and a specificity of 64.00%.The positive predictive value and negative predictive value were 92.13% and 76.19%.The area under curve(AUC) of receiver operating characteristic curve (ROC) was 0.75.Conclusion Age,gender,hypertension,type 2 diabetes mellitus,and low HDL-C correlate with CHD and have a high sensitivity and specificity for the diagnosis of CHD.