Abstract: ObjectiveTo build a decision-making system for prevention and treatment of hemorrhagic fever with renal syndrome(HFRS)using spatial information technology and information visualization technology.MethodsUnder the support of Windows XP system,ArcGIS Engine 9.2 and Visual Basic 6.0 were used to develop modules for a visualization system,which compiled geographic database,attribute database,and knowledge database with each other closely by Activex Data Object.This visualization system,with geographic information system(GIS)as the core of information,can transform HFRS-related information into knowledge which is important for decision makers.ResultsThe decision-making system for the prevetion and treatment of HFRS,which could comprehensively integrate HFRS monitoring data,animal host data and related geographical environment data and provide tools for field epidemiology investigation,data management and analysis, differential diagnosis,animal host identification,mapping and data export functionality for facilitating multi-departmental data sharing,was established.Conclusioncombining the geospatial data with the diversity of epidemiological data and combining the traditional GIS with multi-information visualization technologies could lead to effective application of spatial information technology in the decision-making of disease prevention and treatment.