Abstract: ObjectiveTo describe and analyze the levels and risk factors for 12-month comorbidity of mood,anxiety and alcohol-use disorders among the residents of Liaoning province.MethodsTotally 1 214 subjects diagnosed with mental disorders by the Diagnostic and Statistical Manual of Mental Disorders-Ⅲ-Revised(DSM-Ⅲ-R)criteria were derived from the Mental Health Survey in Liaoning province.Logistic regression was used to calculate the relative risks of major risk factors for comorbid disorders using subjects with pure disorder as the reference group.ResultsThe comorbid anxiety and mood disorder was the most common comorbid condition.Divorce was significantly associated with the 3-5 times increased risks of comorbid mood and anxiety,comorbid anxiety and mood,and comorbid alcohol use disorder with mood or anxiety disorders.The female has a significantly higher risk of comorbid alcohol use disorder with mood or anxiety disorders than the male(odds ratioOR=5.28,95% confidence intervalCI:1.84-15.15).Rural residents had a significantly lower risk of comorbid anxiety and mood then urban residents(OR=0.57,95% CI=0.36-0.92).ConclusionPsychiatric comorbidity is a common phenomenon among the residents of Liaoning province and the prevention,diagnosis and treatment of comorbid psychiatric disorders need to be improved.