Abstract: Objective To investigate the influencing factors of primary lung adenocarcinoma.Methods The subjects included 306 lung adenocarcinoma cases and 437 age-gender-matched health controls recruited from local population.The odds ratios(ORs) and their 95% confidence interval(CI) of all factors which entered unconditional logistic regression model were calculated.Results In multivariate unconditional logistic regression analysis,ambient air pollution,insufficient indoor ventilation,indoor cooking oil fume,smoking pack-year > 30,environmental tabacco smoking (ETS) at home and work place,usage of pesticide,and major adverse event in last 10 years were risk factors of lung adenocarcinoma with the adjusted ORs of 2.127 (95% CI:1.339-3.377),2.271 (95% CI:1.388-3.715),4.177 (95% CI:1.459-11.958),2.422(95% CI:1.339-4.381),1.511(95% CI:1.032-2.212),2.292(95% CI:1.442-3.642),and 2.354(95% CI:1.243-4.456),respectively.Cooking with medium temperature,intake of green tea,and frequent physical activity in last 10 years were protective factors of lung adenocarcinoma with the adjusted ORs of 0.416(95% CI:0.259-0.667),0.471(95% CI:0.276-0.802),and 0.442(95% CI:0.292-0.669).The interaction effects between ambient air pollution and cooking oil fume,ETS at home and work place were indentified among all influential factors.There were some differences in the influencing factors between the men and the women.Conclusion Ambient air pollution,insufficient indoor ventilation,cooking oil fume,smoking,ETS at home and work place,usage of pesticide,and major adverse event in last 10 years could increase the risk of lung adenocarcinoma.Cooking with medium temperature,intake of green tea,and frequent physical activity in last 10 years may reduce the risk of lung adenocarcinoma.