Abstract: Objective To explore the association between the clustering of dyspnea,emotion,interpersonal relation,and fatigue and sleep quality.Methods A total of 3 225 residents aged 18-55 years in Suzhou city were selected through cluster sampling and surveyed about sleep quality and the influencing factors.Results The prevalence of poor sleep quality was 16.43%.There were significant differences in the prevalence among the residents with different occupation,marital status,education level,dyspnea,emotion,interpersonal relation,and fatigue(P< 0.01).The results of logistic regression show ed that dyspnea,bad emotion,bad interpersonal relation,fatigue and negative character increased the risk of poor sleep quality,with the adjusted odds ratios OR of 6.64,6.79,4.16,5.17,and 2.83,respectively (all P<0.001) and the adjusted OR of sleep quality for the residents with the clustering of 1,2,3 or more influencing factors were 4.89,15.17,and 52.29,respectively(all P< 0.001).The risk of poor sleep quality increases with the number of clustering of the influencing factors according to the results of trend test.Conclusion The risk of poor sleep quality increases with the number of clustering of the influencing factors.