Abstract: Objective To analyze the test indicators influencing the prognosis of severe hepatitis and to determine their relations with the prognosis of the patient and to provide reference for treatment of severe hepatitis. Methods A total of 294 medical records of severe hepatitis inpatients in a hospital from March 2009 to March 2013 were analyzed retrospectively.Univariate and multivariate logistic regression analyses were used to examine associations of test indicators with the prognosis of the severe hepatitis. Results After adjusting the confounding factors such as gender,age,and disease classification and complications,prothrombin time(PT)(odds ratioOR=2.474,95% confidence interval95% CI=1.172-4.793,platelet count(PLT)(OR=1.118,95% CI=1.123-2.672),blood urine nitrogen(BUN)(OR=1.436,95% CI=1.011-2.874),and viral DNA loads(OR=1.925,95% CI=1.117-3.018)were the main indexes related to prognosis of severe hepatitis. Conclusion PT,BUN,PLT and viral load are major test indicators affecting the prognosis of severe hepatitis.