Abstract: Objective To examine the two-week morbidity rate of diseases and its major influential factors in the residents aged 15 years or older in Dandong city and to provide scientific basis for disease prevention and control and the establishment of regional health planning.Methods Overal 10 930 people from 5 000 families were selected randomly by means of stratified-cluster sampling and surveyed with a standardized questionnaire.Non-conditional stepwise logistic regression was employed to explore the influencing factors.Results Among the residents,the two-week prevalence of diseases was 14.96%(17.88% for urban residents and 13.34 for rural residents).The influncial factors of the two-week prevalence were gender,age,marital status,educational level,occupation,and suffering from chronic diseases based on the results of non-conditional stepwise logistic regression.The five top morbidity diseases were upper respiratory tract infection,hypertension,influenza,coronary heart disease,and gastroenteritis.Conclusion Widowed,low education,retired and suffering from chronic diseases are important risk factors for increased two-week prevalence of diseases among the residents of Dandong city.Strengthening disease prevention and providing more health services are most important measures for improving the health of residents in Dandong city.