Abstract: Objective To explore the association between potentially functional polymorphisms of rs2536(T>C)and rs1883965(G>A)in mammalian target of rapamycin(mTOR)and the risk of hepatocellular carcinoma(HCC), and to provide a reference for prevention of HCC.Methods A hospital-based case-control study was carried out.Totally 1 048 HCC patients and 1 052 cancer-free patients from the First Affiliated Hospital of Guangxi Medical University and Guangxi Cancer Hospital during January 2007- April 2011 were investigated with a questionnaire survey.Polymorphisms were genotyped for rs2536 and rs1883965 in the cases and controls.The associations between polymorphisms of rs2536 and rs1883965 in mTOR and its interaction with environmental factors and the risk of HCC were analyzed with logistic regression model.Results No significant differences were found in the genotype distributions of rs2536 and rs1883965(P>0.05)between the cases and controls.The frequency of the TT, TC, CC, and TC+CC genotypes of rs2536 were 81.01%, 17.75%, 1.24%, and 18.99%in the cases and 80.80%, 17.87%, 1.33, and 19.20% in the controls, respectively.The frequency of the GG, GA, AA, and GA+AA genotypes of rs1883965 were 84.06%, 15.74%, 0.19%, and 15.94%in cases and 83.84%, 15.21%, 0.95%, and 16.16%in the controls, respectively.After stratified by age, sex, race, smoking status, alcohol drinking, and hepatitis B virus infection, no statistically significant associations were found.Conclusion No association between polymorphisms of rs2536(T>C)and rs1883965(G>A)in mTOR and the risk of HCC was found in Guangxi population in the study.