济南市女性膳食模式与非酒精性脂肪肝病关系

赫英英; 魏颖; 厉玉婷; 刘国红; 张成琪; 于红霞

doi:10.11847/zgggws2014-30-09-02

济南市女性膳食模式与非酒精性脂肪肝病关系

doi: 10.11847/zgggws2014-30-09-02

山东大学公共卫生学院营养与食品卫生研究所, 山东济南 250012

基金项目:

国家自然科学基金（81273082）

详细信息

作者简介:
赫英英（1988- ），女，满族，吉林集安人，硕士在读，研究方向：营养与食品卫生学。

通讯作者:
于红霞，yuhx@sdu.edu.cn

中图分类号: R575.5
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出版历程
- 接收日期: 2013-09-09
- 刊出日期: 2014-09-10

Association between dietary pattern and nonalcoholic fatty liver disease in female population in Jinan city

Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Ji'nan, Shandong Province 250012, China

摘要

摘要: 目的探讨山东省济南市女性人群不同膳食模式与非酒精性脂肪肝病（NAFLD）的关系，为NAFLD的预防控制提供参考依据。方法随机抽取2010年11月—2012年7月在济南市某三甲医院进行健康体检的1 354名女性进行膳食调查、体格检查和实验室检测；采用因子分析和多因素logistic 回归模型分析主要膳食模式及其与NAFLD之间的关系。结果济南市女性人群NAFLD患病率为8.4%；因子分析共得到鱼肉类模式、杂粮蔬菜类模式、油谷类模式、糕点饮料类模式、蛋奶类模式5 种膳食模式，累积方差贡献率为50.54%；调整年龄和体质指数（BMI）后，多因素logistic 回归分析结果显示，鱼肉类模式（OR=0.49，95%CI=0.28~0.87）和糕点饮料类模式（OR=1.84，95%CI=1.07~3.14）与NAFLD患病有关；进一步分析不同膳食模式与NAFLD关系，调整年龄和BMI后，结果显示，鱼肉类模式得分最高四分位数者患NAFLD的危险性为最低四分位数者的5.00倍（OR=5.00，95%CI=1.04~23.90），油谷类模式得分第二四分位数者患NAFLD的危险性为最低四分位数者的0.38倍（OR=0.38，95%CI=0.16~0.90），糕点饮料类模式得分第三分位数者患NAFLD的危险性为最低四分位数者的0.36倍（OR=0.36，95%CI=0.13~0.99）。结论鱼虾类、畜禽肉类、糕点及饮料等食物摄入过多可增加女性患NAFLD的危险性。
- 膳食模式 /
- 非酒精性脂肪肝病(NAFLD) /
- 女性
Abstract: Objective To explore the relationship between different dietary pattern and nonalcoholic fatty liver disease(NAFLD)and to provide the reference for the prevention and control of NAFLD in female population of Ji'nan city.Methods Totally 1 354 women having a physical examination in a 3A grade hospital in Ji'nan from November 2010 to July 2012 were randomly selected for a dietary survey and anthropometric and biochemical measurements.Factor analysis and multivariate logistic regression model were used to analyze the association of dietary patterns with NAFLD.Results The detection rate of NAFLD in the female population was 8.4%.Five dietary patterns,namely meat and fish,grains and vegetable,oil cereals,pastries beverage,and eggs and milk pattern,were identified through factor analysis,with a cumulative variance contribution rate of 50.54%.After adjusting for age and body mass index(BMI),multiple logistic regression analysis showed that meat and fish pattern(odds ratio[OR]=0.49,95% confidence interval[95% CI]:0.28-0.87)and pastries beverages pattern(OR=1.84,95%CI=1.07-3.14) were associated with NAFLD.Furthermore,dietary pattern scores were categorized into quartiles to conduct multivariate logistic regression analysis.After adjustment for age and BMI,the results displayed that the females in the highest quartile for the meat and fish dietary pattern had a 5.00 times greater odds of NAFLD(OR=5.00,95% CI 1.04-23.90)compared with those in the lowest quartile.The females in the second quartile of oil cereals pattern scores had a lower risk of NAFLD(OR=0.38,95% CI=0.38-0.90)compared to those in the lowest quartile of the score.The females in the third quartile of pastries beverage pattern scores had a lower risk of NAFLD(OR=0.36,95% CI=0.36-0.99)compared to those in the lowest quartile of the score.Conclusion Excessive intake of fish and shrimp,poultry meat,cakes and beverages may increase the risk of NAFLD in female population.
- dietary pattern /
- nonalcoholic fatty liver disease(NAFLD) /
- female

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参考文献(17)

[1]	Fan JG,Farrell GC.Epidemiology of non-alcoholic fatty liver disease in China[J].J Hepatol,2009,50(1):204-210.
[2]	Schwimmer JB,Deutsch R,Kahen T,et al.Prevalence of fatty liver in children and adolescents[J].Pediatrics,2006,118(4):1388-1393.
[3]	赵广香.脂肪肝与饮食及生活习惯的相关危险因素分析[J].现代中西医结合杂志,2008,17(36):5665-5667.
[4]	Shira ZS,Nitzan KD,Goldsmith R,et al.Long term nutritional intake and the risk for non-alcoholic fatty liver disease(NAFLD):a population based study[J].J Hepatol,2007,47(5):711-717.
[5]	Wendy HO,Carly EH,Peter J,et al.The western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence[J].Am J Gastroenterol,2013,108(5):778-785.
[6]	中国营养学会.中国居民膳食指南及平衡膳食宝塔[M].拉萨:西藏人民出版社,2008:172-177.
[7]	翟凤英,杨晓光.中国居民营养与健康状况调查报告之二2002膳食与营养素摄入状况[M].北京:人民卫生出版社,2006:46-54.
[8]	黄锦荣,梁海燕.脂肪肝与其相关因素的logistic回归分析[J].现代预防医学,2008,35(9):1603-1605.
[9]	王文娟,王克安,李天麟,等.体重指数、腰围和腰臀比预测高血压、高血糖的实用价值及其建议值探讨[J].中华流行病学杂志,2002,23(1):16-19.
[10]	中华医学会肝病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南(2010年修订版)[J].中华肝脏病杂志,2010,18(3):163-166.
[11]	张家放.医用多元统计方法[M].武汉:华中科技大学出版社,2002:315-316.
[12]	土旭东,王斌,王强.事业单位人员脂肪肝患病率及危险因素分析[J].中国公共卫生,2011,27(7):1177-1179.
[13]	王亚莉,朱明宇,赵杉,等.某高校女性教职工BMI、WHR与脂肪肝相关性[J].中国公共卫生,2011,27(4):438-440.
[14]	刘淑芬,曾学军.体检人群中高尿酸血症与脂肪肝的相关性[J].中华临床免疫和变态反应杂志,2011,5(2):109-112.
[15]	Jeffrey CS,Kim MF,Giovanni T,et al.Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States:liver ultrasound data from the National Health and Nutrition Examination Survey[J].Metabolism,2013,62(3):392-399.
[16]	Baldwin W,McRae S,Marek G,et al.Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome[J].Diabetes,2011,60(4):1258-1269.
[17]	Ambrosini GL,Huang RC,Mori TA,et al.Dietary patterns and markers for the metabolic syndrome in Australian adolescents[J].Nutr Metab Cardiovasc Dis,2010,20(4):274-283.