Abstract: Objective To explore the prevalence,transmission and spread factors of sever fever with thrombocytopenia syndrome(SFTS)bunyavirus and the mechanism of human-to-human transmission of the virus.Methods Descriptive epidemiological method was adopted to analyze the relationship between spread factors and the incidence of SFTS.Results Totally 3 cases(a father and his two sons)were identified in the SFTS epidemic in a family.The first case was the father with the history of tick bite;the 2 secondary cases were the two sons with history of contact with blood,secretion or excrement of the initial case.Conclusion The epidemic is the first SFTS human-to-human transmission in the western region of Anhui province of China and the SFTS epidemic suggests the infection of bunyavirus is related to tick bite and contact with blood,secretion or excrement of infected case.