ACE基因多态性与缺血性脑卒中易感性关系

张振昶; 陈丽霞; 武国德; 李鸣明; 苏刚; 李鑫

doi:10.11847/zgggws2014-30-09-31

ACE基因多态性与缺血性脑卒中易感性关系

doi: 10.11847/zgggws2014-30-09-31

1.
兰州大学第二医院神经内科, 甘肃兰州 730030;
2.
兰州大学基础医学院

基金项目:

甘肃省科技支撑项目（1104FKCA115）

详细信息

作者简介:
张振昶（1977- ），男，甘肃兰州人，副主任医师，硕士，主要从事神经内科的临床诊疗工作。

中图分类号: R743.3
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出版历程
- 收稿日期: 2013-04-07
- 刊出日期: 2014-09-10

Relationship between genetic polymorphism of ACE gene and ischemic stroke

1.
Department of Neurology, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province 730030, China

摘要

摘要: 目的探讨ACE基因多态性与缺血性脑卒中的相关性。方法采用回顾性病例-对照研究的方式，选取166例脑卒中患者与120名正常健康人群，采用聚合酶链反应（PCR）与直接测序法对其ACE基因进行基因分型。结果 PCR分型结果显示，病例组中ACE基因I/D分型中，D/D型、I/D型与I/I型频率分别为71.1%、24.7%与4.2%；而对照组D/D型、I/D型与I/I型频率分别为50.8%、41.7%与7.5%，2组差异有统计学意义；D/D型基因携带者患缺血性脑卒中的风险是I/D型与I/I型基因携带者的2.38倍（95%CI=1.463～3.872）和2.79倍（95%CI=1.914～4.167）。结论携带D/D型基因的人群患缺血性脑卒中风险明显高于携带I等位基因的人群。
- 血管紧张素转换酶(ACE) /
- 缺血性脑卒中 /
- 基因多态性
Abstract: Objective To investigate the relationship between genetic polymorphism of angiotension-converting enzyme(ACE) gene and ischemic stroke.Methods Polymerase chain reaction(PCR)and DNA sequencing were used to detect ACE genotypes in 166 patients with ischemic stroke and 120 healthy controls in a Han population.Results Among the cases with ischemic stroke,the I/D frenquencies of D/D,I/D,I/I were 71.1%,24.7%,4.2%,and that of the controls were 50.8%,41.7%,7.5%,respectively.There were significant differences between the two groups.The relative risk of suffering from ischemic stroke in D/D gene carriers was 2.38 and 2.79 times compared to I/D and I/I gene carriers(95% confidence interval[95%CI] of I/I=1.463-3.872 and 95%CI of I/D=1.914-4.167),and the differences were statistically significant(P<0.05).Conclusion ACE polymorphism is associated with ischemic stroke.The ACE gene D/D allele carriers have a significantly higher risk of ischemic stroke than other genotype carriers and D/D allele may be a genetic susceptibility gene for ischemic stroke.
- angiotension-converting enzyme /
- ischemic stroke /
- gene polymorphism

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参考文献(10)

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