Abstract: Objective To observe the protective effect of germanium(Ge)-enriched Gnoderma lucidum on tetrachloromethane(CCl4)-induced acute hepatic injury in rats.Methods Fifty rats were divided into 5 groups(normal group,CCl4 model group,high-,moderate-,and low-dose groups with Ge-enriched Gnoderma lucidum at the dosages of 450,230,and 80 mg/kg via gavage).The rat acute hepatic injury model was induced by CCl4.The serum level of alanine transaminase(ALT)and aspartate transaminase(AST)were determined and pathologic changes of hepatic tissues were examined.Results Compared with those of the rats in the control gropu,the serum ALT and AST and the liver damage in the rats of the experimental hepatic injury groups were markedly decreased after the administration of moderate and low dose of Ge-enriched Ganoderma lucidum.Conclusion Ge-enriched Ganoderma lucidum has protective effect on CCl4-induced hepatic injury in rat.