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孕期补锌对新生儿健康影响随机对照试验meta分析

谢仕兰 陆敏珊 罗伟平 张彩霞

谢仕兰, 陆敏珊, 罗伟平, 张彩霞. 孕期补锌对新生儿健康影响随机对照试验meta分析[J]. 中国公共卫生, 2015, 31(2): 227-231. doi: 10.11847/zgggws2015-31-02-29
引用本文: 谢仕兰, 陆敏珊, 罗伟平, 张彩霞. 孕期补锌对新生儿健康影响随机对照试验meta分析[J]. 中国公共卫生, 2015, 31(2): 227-231. doi: 10.11847/zgggws2015-31-02-29
XIE Shi-lan, LU Min-shan, LUO Wei-ping.et al, . Effects of zinc supplementation during pregnancy on neonatal health:a meta-analysis of randomized controlled trials[J]. Chinese Journal of Public Health, 2015, 31(2): 227-231. doi: 10.11847/zgggws2015-31-02-29
Citation: XIE Shi-lan, LU Min-shan, LUO Wei-ping.et al, . Effects of zinc supplementation during pregnancy on neonatal health:a meta-analysis of randomized controlled trials[J]. Chinese Journal of Public Health, 2015, 31(2): 227-231. doi: 10.11847/zgggws2015-31-02-29

孕期补锌对新生儿健康影响随机对照试验meta分析

doi: 10.11847/zgggws2015-31-02-29
基金项目: 

2012中国营养学会营养科研基金帝斯曼专项科研基金

详细信息
    作者简介:

    谢仕兰(1989-),女,广东兴宁人,硕士在读,研究方向:疾病预防与控制。

    通讯作者:

    张彩霞,E-mail:zhangcx3@mail.sysu.edu.cn

  • 中图分类号: R174+.1

Effects of zinc supplementation during pregnancy on neonatal health:a meta-analysis of randomized controlled trials

  • 摘要: 目的 采用meta分析方法系统定量评价健康孕妇孕期补锌对新生儿出生体重、出生身长、出生头围、早产、低出生体重和围生期死亡的影响,为孕妇合理补锌提供充分的科学依据。方法 检索Pubmed、OVID、EMBASE、WOK、SCOPUS和万方、中国生物医学文献数据库等多个中英文数据库的相关文献,收集所有关于孕妇孕期补充锌与新生儿出生体重、出生身长、出生头围、早产、低出生体重和围生期死亡关系的随机对照试验原始研究数据,应用Rev Man 5.2软件进行meta分析。结果 共纳入符合要求的原始文献15篇,包括14篇英文文献和1篇中文文献;meta分析结果显示,孕期补锌对出生体重影响的MD=18.13(95%CI=-26.72~62.99),对出生身长影响的MD=-0.10(95%CI=-0.24~0.03),对出生头围影响的MD=-0.04(95%CI=-0.13~0.05),对早产影响的相对危险度RR=0.84(95%CI=0.74~0.96),对低出生体重影响的RR=0.85(95%CI=0.66~1.11),对围生期死亡影响的RR=1.27(95%CI=0.68~2.38);孕期干预组单独补充锌对出生体重影响的MD=-30.73(95%CI=-86.82~25.35),对早产影响的RR=0.89(95%CI=0.71~1.11),对低出生体重影响的RR=0.77(95%CI=0.44~1.37);而含锌的多种微量营养素联合补充对出生体重影响的MD=38.13(95%CI=-20.60~96.85),对出生身长影响的MD=-0.08(95%CI=-0.24~0.08),对出生头围影响的MD=-0.02(95%CI=-0.18~0.13),对早产影响的RR=0.78(95%CI=0.64~0.95),对低出生体重影响的RR=0.80(95%CI=0.51~1.26)。结论 孕期单独补充锌可降低早产的发生,但对新生儿出生体重、出生身长、出生头围、低出生体重和围生期死亡无影响。
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出版历程
  • 收稿日期:  2013-12-09
  • 刊出日期:  2015-02-10

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