Abstract: ObjectiveTo investigate the effect of Qige-Shancai compound capsule(QSCC,a mixture of astragalus,kudzu root,Gynura divaricata,and wolfberry fruit with total saponins of 350 mg/100 g and puerarin of 1.5 g/100 g) on mice with high blood glucose.MethodsSixty special pathogen free(SPF) adult Kunming mice were randomly divided into 6 groups(10 mice in each group):solvent control,QSCC control,model,and low-,medium-,high-dose groups administered with QSCC of 0.45,0.90,1.35 g/kg by gavage once a day for 30 days.High blood glucose of the mice were induced by injecting alloxan through caudal vein.General growth status and weight change in the mice were observed ; fasting blood glucose was measured with glucometer; and changes in the area under the curve of blood glucose determined with glucose tolerance test were compared among the groups.ResultsBody weight and weight gain showed no significant differences between the solvent control and the other groups.Compared with that of the control group,fasting blood glucose significantly increased in the model group(21.15±1.76 vs.5.57±1.19 mmol/L)(P<0.01).Compared with the model group,fasting blood glucose of the mice in 0.90 and 1.35 g/kg QGCC groups decreased to 15.96±1.91 and 15.43±2.19 mmol/L significantly(both P<0.01) with the decrease rates of 19.97±12.79% and 24.22±16.47%.A significant decline in the area under blood glucose curve was observed in the mice treated with 1.35 g/kg QGCC compared with the model group(52.70±5.44 vs.57.22±3.83)(P<0.01),but no significant effect of 1.35 g/kg QGCC on fasting blood glucose was observed in normal mice.ConclusionQGCC could reduce fasting blood glucose of mice with high blood glucose and has no significant impact on general growth in mice.