Abstract: ObjectiveTo explore protein expressions of epithelial growth factor receptor(EGFR),p53,and fascin in nasopharyngeal carcinoma tissue and their clinical significance.MethodsImmunohistochemical method was used to detect protein expressions of EGFR,p53,and fascin in nasopharyngeal carcinoma tissue and adjacent normal tissue among 88 nasopharyngeal carcinoma inpatients randomly selected at a municipal hospital of Zhengzhou city from January 2009 through October 2011.Associations of EGFR,p53,and fascin expressions with prognosis and clinical-pathologic features of nasopharyngeal carcinoma were analyzed.ResultsThe positive rates of EGFR and fascin expressions in nasopharyngeal carcinoma tissue(82.95% and 92.05%)were significantly higher than those in the adjacent carcinoma normal tissue(0.23% and 9.09%)(both P<0.001);while the positive rate of p53 expression(12.50%)in nasopharyngeal carcinoma tissue was significantly lower than that in the adjacent carcinoma normal tissue(88.64%,P<0.001).ConclusionEGFR and fascin protein expression rate is high while p53 expression rate is low in nasopharyngeal carcinoma tissues and the expressions relate with clinical-pathological features and prognosis of the carcinoma.