Abstract: Objective To analyze the trend and characteristics of acute hepatitis B incidents in Jiangxi province and to provide information for making prevention measures.Methods Data on incidence of acute hepatitis B were collected from National Notifiable Disease Reporting System(NNDRS).Descriptive epidemiological methods were adopted in data analysis.Results A total of 26 448 acute hepatitis B cases were reported through NNDRS and the average incidence was 6.71/100000 during the period of 2005 through 2013,with a declined reported incidence rate from 8.00/100000 in 2005 to 4.18/100000 in 2013.Most of the cases occurred between March to August of a year.Pingxiang municipality had the highest average incidence(26.29/100000),while Jiujiang municipality had the lowest(3.12/100000),with significant regional disparity(χ²=11 898.39,P<0.0001).Of all the cases reported,62.78%were at the age between 15 and 39 years,77.37%were male,and 52.2%were peasants.Conclusion There is a decreasing trend in acute hepatitis B incidence,with the majority of the cases of male peasants aged 15-39 years and a huge regional disparity in Jiangxi province during 2005-2013.