Establishment and evaluation of silencer model in Beagle dogs
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摘要: 目的 建立Beagle犬消声模型并评价切断右侧喉返神经对犬生理功能影响。方法 普通级健康Beagle犬12条,随机分为模型组及对照组;模型组犬麻醉后,通过外科手术切断其右侧喉返神经,分别于术后3、6个月检测犬的吠叫音量;同时,检测Beagle犬心电图、呼吸、血液生理及血液生化指标。结果 术后3、6个月时,对照组与模型组犬吠叫音量分别为(41.83±4.87)、(48.62±2.19)dB(A)与(33.04±2.34)、(35.20±1.98)dB(A),模型组Beagle犬吠叫音量均低于对照组(均P<0.05);术后3、6个月时,与对照组比较,模型组Beagle犬22项血液生理指标和8项血液生化指标差异均无统计学意义(均P>0.05);术后3、6个月时,与对照组比较,模型组Beagle犬呼吸运动及心电图指标差异均无统计学意义(均P>0.05)。结论 损伤单侧喉返神经可明显降低Beagle犬的吠叫音量,且术后犬的血液学、心电图、呼吸指标均无明显变化。Abstract: Objective To establish silencer model in Beagle dogs and to evaluate physiological function of Beagle dogs with right recurrent laryngeal nerve amputation.Methods Twelve healthy Beagle dogs were randomly divided into a model and a control group;right recurrent laryngeal nerve amputation was performed in the dogs of the model group.Barking volume was measured for all the Beagle dogs at 3- and 6-month of the experiment and electrocardiogram,respiration function,and physiological and biochemical indicators of blood of the Beagle dogs were determined simultaneously.Results The barking volumes were 41.83±4.87 and 48.62±2.19 dB(A)for the control group and 33.04±2.34 and 35.20±1.98 dB(A)for the model group at 3- and 6-month,with significantly lower volumes in the Beagle dogs of model group compared to those of the control group(both P<0.05).No significant differences in electrocardiogram,respiration function,22 blood physiological indicators,and 8 blood biochemical indicators were observed between the control and model groups at 3- and 6-month of the experiment(P>0.05 for all).Conclusion Unilateral recurrent laryngeal nerve amputation can significantly reduce barking volume and has no significant impacts on electrocardiogram,respiration function,and hematologic indicators in Beagle dogs.
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Key words:
- recurrent laryngeal nerve injury /
- Beagle dog /
- animal silencer model
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