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MAPK信号转导通路与神经损伤研究进展

刘婷婷 张淑萍 覃筱燕 潘瑞远

刘婷婷, 张淑萍, 覃筱燕, 潘瑞远. MAPK信号转导通路与神经损伤研究进展[J]. 中国公共卫生, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32
引用本文: 刘婷婷, 张淑萍, 覃筱燕, 潘瑞远. MAPK信号转导通路与神经损伤研究进展[J]. 中国公共卫生, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32
LIU Ting-ting, ZHANG Shu-ping, QIN Xiao-yan.et al, . Progress in studies on MAPK signal transduction pathway and nerve injury[J]. Chinese Journal of Public Health, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32
Citation: LIU Ting-ting, ZHANG Shu-ping, QIN Xiao-yan.et al, . Progress in studies on MAPK signal transduction pathway and nerve injury[J]. Chinese Journal of Public Health, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32

MAPK信号转导通路与神经损伤研究进展

doi: 10.11847/zgggws2016-32-02-32
基金项目: 

国家自然科学基金(31372225);中央高校自主科研基金(1112KYZY41);中央民族大学985资助项目(MUC98504-14)

详细信息
    作者简介:

    刘婷婷(1990-),女,黑龙江人,硕士在读,研究方向:鸟类神经生理及神经药理学。

    通信作者:

    覃筱燕,E-mail:bjqinxiaoyan@muc.edu.cn;张淑萍,E-mail:springzsp@sina.com

    覃筱燕,E-mail:bjqinxiaoyan@muc.edu.cn;张淑萍,E-mail:springzsp@sina.com

  • 中图分类号: R741.02

Progress in studies on MAPK signal transduction pathway and nerve injury

  • 摘要: 丝裂原活化蛋白激酶(MAPKs)是一种胞浆内广泛分布的丝氨酸/苏氨酸蛋白激酶,在真核细胞中,由4条平行的信号转导通路组成。细胞外信号调节蛋白激酶1/2(ERK 1/2)通路、c-Jun氨基末端激酶(JNK)和(或)应激活化蛋白激酶(SAPK)通路、p38 丝裂原活化蛋白激酶(p38 MAPK)通路和细胞外信号调节蛋白激酶5(ERK 5)/大丝裂原活化蛋白激酶1(BMKl)通路。近年来的研究发现MAPK信号通路与神经损伤相关。ERK 1/2和p38在神经损伤的区域迅速磷酸化激活,减少神经损伤对机体带来的影响;磷酸化JNK在神经损伤部位聚集,促进神经细胞的凋亡,加重神经损伤的发生;ERK 5是细胞增殖与分化、器官发生与胚胎发育中不可缺少的信号蛋白,磷酸化ERK 5通过促进胰岛素在神经元中的表达促进神经细胞存活。除此之外MAPK各分子在不同刺激和不同疾病中的作用不同。
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  • 接收日期:  2014-06-20
  • 刊出日期:  2016-02-10

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