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MAPK信号转导通路与神经损伤研究进展

刘婷婷 张淑萍 覃筱燕 潘瑞远

刘婷婷, 张淑萍, 覃筱燕, 潘瑞远. MAPK信号转导通路与神经损伤研究进展[J]. 中国公共卫生, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32
引用本文: 刘婷婷, 张淑萍, 覃筱燕, 潘瑞远. MAPK信号转导通路与神经损伤研究进展[J]. 中国公共卫生, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32
LIU Ting-ting, ZHANG Shu-ping, QIN Xiao-yan.et al, . Progress in studies on MAPK signal transduction pathway and nerve injury[J]. Chinese Journal of Public Health, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32
Citation: LIU Ting-ting, ZHANG Shu-ping, QIN Xiao-yan.et al, . Progress in studies on MAPK signal transduction pathway and nerve injury[J]. Chinese Journal of Public Health, 2016, 32(2): 248-254. doi: 10.11847/zgggws2016-32-02-32

MAPK信号转导通路与神经损伤研究进展

doi: 10.11847/zgggws2016-32-02-32
基金项目: 

国家自然科学基金(31372225);中央高校自主科研基金(1112KYZY41);中央民族大学985资助项目(MUC98504-14)

详细信息
    作者简介:

    刘婷婷(1990-),女,黑龙江人,硕士在读,研究方向:鸟类神经生理及神经药理学。

    通讯作者:

    覃筱燕,E-mail:bjqinxiaoyan@muc.edu.cn;张淑萍,E-mail:springzsp@sina.com

    覃筱燕,E-mail:bjqinxiaoyan@muc.edu.cn;张淑萍,E-mail:springzsp@sina.com

  • 中图分类号: R741.02

Progress in studies on MAPK signal transduction pathway and nerve injury

  • 摘要: 丝裂原活化蛋白激酶(MAPKs)是一种胞浆内广泛分布的丝氨酸/苏氨酸蛋白激酶,在真核细胞中,由4条平行的信号转导通路组成。细胞外信号调节蛋白激酶1/2(ERK 1/2)通路、c-Jun氨基末端激酶(JNK)和(或)应激活化蛋白激酶(SAPK)通路、p38 丝裂原活化蛋白激酶(p38 MAPK)通路和细胞外信号调节蛋白激酶5(ERK 5)/大丝裂原活化蛋白激酶1(BMKl)通路。近年来的研究发现MAPK信号通路与神经损伤相关。ERK 1/2和p38在神经损伤的区域迅速磷酸化激活,减少神经损伤对机体带来的影响;磷酸化JNK在神经损伤部位聚集,促进神经细胞的凋亡,加重神经损伤的发生;ERK 5是细胞增殖与分化、器官发生与胚胎发育中不可缺少的信号蛋白,磷酸化ERK 5通过促进胰岛素在神经元中的表达促进神经细胞存活。除此之外MAPK各分子在不同刺激和不同疾病中的作用不同。
  • [1] Mossman BT,Lounsbury KM,Reddy SP.Oxidants and signaling by mitogen-activated protein kinases in lung epithelium[J].American Journal of Respiratory Cell and Molecular Biology,2006,34(6):666-669.
    [2] Liu X,Zhu J,Tian B,et al.Activations of P-p38 MAPK and caspase-3 in NMDA-induced cultured cortical neurons in vitro and the protective effect of SB203580[J].Journal of Shandong University(Health Sciences),2012,50(6):10-15.
    [3] 李亚男,金英.MAPK信号转导通路在阿尔茨海默病中作用的研究进展[J].辽宁医学院学报,2008,15(1):35-35.
    [4] 张美荣,刘举,王洋.丝裂原激活蛋白激酶相关疾病及其药物的研究进展[J].中国药物化学杂志,2014,24(3):231-240.
    [5] 周正,朱云祥,李强,等.MAPK信号转导通路中ERK,JNK和P38在大鼠肝脏缺血再灌注和缺血后处理中表达的变化[J].中国组织工程研究与临床康复,2009,13(15):2919-2922.
    [6] 焦俊霞,高维娟.细胞凋亡的信号转导机制研究进展[J].中国老年学杂志,2010,30(6):853-856.
    [7] Morimoto H,Kondoh K,Nishimoto S,et al.Activation of a C-terminal transcriptional activation domain of ERK 5 by autophosphorylation[J].Journal of Biological Chemistry,2007,282(49):35449-35456.
    [8] 梁艳芳,卿燕,杜清清,等.三甲基氯化锡诱导PC12细胞凋亡的机制[J].中华劳动卫生职业病杂志,2012,30(11):816-819.
    [9] Gustavsson M,Barmark G,Larsson J,et al.Functional genomics of monensin sensitivity in yeast:implications for post-Golgi traffic and vacuolar H+-ATPase function[J].Molecular Genetics and Genomics,2008,280(3):233-248.
    [10] Zhang J,Zhi H,Zhou C,et al.Up-regulation of fibronectin in oesophageal squamous cell carcinoma is associated with activation of the Erk pathway[J].The Journal of Pathology,2005,207(4):402-409.
    [11] Goalstone ML.ERK 5:A Novel IKK-kinase in rat hippocampal neurons[J].The Canadian Journal of Neurological Sciences,2011,38(4):639-648.
    [12] Nishimoto S,Kusakabe M,Nishida E.Requirement of the MEK5-ERK 5 pathway for neural differentiation in Xenopus embryonic development[J].EMBO Reports,2005,6(11):1064-1069.
    [13] Ma B,Meng X,Wang J,et al.Notoginsenoside R1 attenuates amyloid--induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation[J].International Immunopharmacology,2014,22(1):151-159.
    [14] 王刚,邓存良.MAPK通路与肝纤维化[J].西南军医,2010,12(3):514-516.
    [15] 郝慧琴,王蕴红.JNK转导通路在细胞凋亡中的作用[J].首都体育学院学报,2007,19(4):18-41.
    [16] Chun JM,Nho KJ,Kim HS,et al.An ethyl acetate fraction derived from Houttuynia cordata extract inhibits the production of inflammatory markers by suppressing NF-B and MAPK activation in lipopolysaccharide-stimulated RAW 264.7 macrophages[J].BMC Complementary and Alternative Medicine,2014,14(1):234-245.
    [17] Lu Q,Rau TF,Harris V,et al.Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures[J].European Journal of Neuroscience,2011,34(7):1093-1101.
    [18] Huang YN,Lai CC,Chiu CT,et al.L-ascorbate attenuates the endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation and NF-B translocation in cortical neurons/glia cocultures[J].PloS One,2014,9(7):e97276.
    [19] Corra SAL,Eales KL.The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease[J].Journal of Signal Transduction,2012,2012:649072.
    [20] Nashida T,Takuma K,Fukuda S,et al.The specific Na(+)/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells[J].Neurochemistry International,2011,59(1):51-58.
    [21] Kanterman J,Sade-Feldman M,Baniyash M.New insights into chronic inflammation-induced immunosuppression[C].Seminars in Cancer Biology,Academic Press,2012,22(4):307-318.
    [22] 杜昆,李琦,周名,等.MAPK/ERK信号通路参与沙眼衣原体抑制TNF-诱导的细胞凋亡[J].中国皮肤性病学杂志,2014,28(5):444-447.
    [23] 甄军丽,王维平,安立伟,等.p38丝裂原活化蛋白激酶通路及其相关神经系统方面的研究进展[J].脑与神经疾病杂志,2010,18(4):318-321.
    [24] Eltzschig HK,Eckle T.Ischemia and reperfusion-from mechanism to translation[J].Nature Medicine,2011,17(11):1391-1401.
    [25] Morente V,Prez-Sen R,Ortega F,et al.Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery[J].Biochimica et Biophysica Acta(BBA)-Molecular Cell Research,2014,1843(9):1886-1898.
    [26] Ashraf MI,Ebner M,Wallner C,et al.A p38 MAPK/MK2 signaling pathway leading to redox stress,cell death and ischemia/reperfusion injury[J].Cell Communication and Signaling,2014,12(1):6-19.
    [27] Grio A,Montero J C,Pandiella A,et al.Erk5 is activated and acts as a survival factor in mitosis[J].Cellular Signaling,2007,19(9):1964-1972.
    [28] 程群,朱汉民,甘洁民,等.ERK 5调节成骨细胞功能的研究[J].中国骨质疏松杂志,2008,12(14):845-848.
    [29] Sohn SJ,Lewis GM,Winoto A.Non-redundant function of the MEK5-ERK 5 pathway in thymocyte apoptosis[J].The EMBO Journal,2008,27(13):1896-1906.
    [30] Pan YW,Kuo CT,Storm DR,et al.Inducible and targeted deletion of the ERK 5 MAP kinase in adult neurogenic regions impairs adult neurogenesis in the olfactory bulb and several forms of olfactory behavior[J].PLoS One,2012,7(11):e49622.
    [31] Anne SL,Govek EE,Ayrault O,et al.WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation[J].PloS One,2013,8(11):e81769.
    [32] 刘美,廖红.Wnt信号通路在神经系统发育和神经系统疾病过程中的作用[J].中国临床药理学与治疗学,2013,18(9):1059-1064.
    [33] Yang S,Zhou G,Liu H,et al.Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia[J].Bio Med Research International,2013,2013:215798.
    [34] Sun HY,Wang NP,Halkos M,et al.Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways[J].Apoptosis,2006,11(9):1583-1593.
    [35] Cheng Y,Cawley NX,Loh YP.Carboxypeptidase E/NF1:a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K/AKT pathways[J].PLoS One,2013,8(8):e71578.
    [36] Kondo T,Sakurai J,Miwa H,et al.Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain[J].Neuroreport,2013,24(2):68-72.
    [37] 王竞,杜俊蓉.缺血性脑损伤机制的研究进展[J].国际药学研究杂志,2008,35(4):302-304.
    [38] Yang XR,Sun P,Qin HP,et al.Involvement of MAPK pathways in NMDA-induced apoptosis of rat cortical neurons[J].Sheng Li Xue Bao:[Acta physiologica Sinica],2012,64(6):609-616.
    [39] Xing B,Bachstetter AD,Van Eldik LJ.Inhibition of neuronal p38,but not p38 MAPK,provides neuroprotection against three different neurotoxic insults[J].Journal of Molecular Neuroscience,2014:1-10.
    [40] Maas AIR,Stocchetti N,Bullock R.Moderate and severe traumatic brain injury in adults[J].The Lancet Neurology,2008,7(8):728-741.
    [41] 边寰,徐浩翔,杨悦凡,等.MAPK信号通路在创伤性脑损伤中的作用[J].中华神经外科疾病研究杂志,2013,12(3):210-213.
    [42] Ashabi G,Alamdary SZ,Ramin M,et al.Reduction of hippocampal apoptosis by intracerebroventricular administration of extracellular signal-regulated protein kinase and/or p38 inhibitors in amyloid beta rat model of Alzheimer's disease:involvement of nuclear-related factor-2 and nuclear factor-B[J].Basic and Clinical Pharmacology and Toxicology,2013,112(3):145-155.
    [43] 罗欣,姚珍薇,漆洪波,等.p38 MAPK抑制剂SB203580对缺氧致人脐静脉内皮细胞损伤的保护作用[J].中国生物制品学杂志,2010,12:1315-1319.
    [44] Lee YJ,Choi SY,Yang JH.NMDA receptor-mediated ERK 1/2 pathway is involved in PFHxS-induced apoptosis of PC12 cells[J].The Science of the Total Environment,2014,491:227-234.
    [45] Di Benedetto B,Radecke J,Schmidt MV,et al.Acute antidepressant treatment differently modulates ERK/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex[J].Neuroscience,2013,232:161-168.
    [46] Xie F,Fang C,Schnittke N,et al.Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile:effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6[J].Toxicology and Applied Pharmacology,2013,272(3):598-607.
    [47] 王小琴,邱一华.白介素-6抗N-甲基-D-天门冬氨酸神经毒性作用的研究[J].南通大学学报:医学版,2006,26(5):316-318.
    [48] Fang XX,Jiang XL,Han XH,et al.Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3,MAPK/ERK,and PI3K/AKT signaling pathways[J].Cellular and Molecular Neurobiology,2013,33(2):241-251.
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  • 收稿日期:  2014-06-20
  • 刊出日期:  2016-02-10

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