Abstract: Objective To explore the status of anxiety and depression for reducing mental disorders among inpatients with brain tumor.Methods An anonymous and self-administered survey was conducted among 205 neurosurgical inpatients with brain tumor using a questionnaire on demography, Perceived Stress Scale(PSS) and The Hospital Anxiety and Depression Scale(HADS) for assessment of anxiety and depression.Results The score for anxiety and depression among the inpatients were 6.86±4.07 and 5.62±3.81 and were both higher than those of national norm for internal medical outpatients(3.30±2.40 and 2.60±2.20).The positive rate of anxiety and depression symptoms were 39.51% and 30.24%, respectively among the inpatients.The results of logistic regression analysis showed that the inpatients with perceived stress were more likely to have anxiety and depression symptoms, with the odds ratio(95% confidence interval) of 1.84(1.102-1.273) and 1.206(1.113-1.306) compared to those without perceived stress.Conclusion Perceived stress is positively correlated with anxiety and depression symptoms among brain tumor inpatients and effective instruction on mental health should be provided to the inpatients for the prevention of these mental disorders.