Abstract: Objective To evaluate the effect and adverse effect of narcotic drugs in elderly people with painless gastroscopy.Methods One thousand eight hundred patients aged ≥60 years undergoing painless gastroscopy were selected by stratified random sampling from July 1,2013 to July 1,2016.According to the use of narcotic drugs,the patients were divided into two groups as PS group (propofol+sufentanil) and ES group (etomidate+sufentanil).The differences in heart rate,blood pressure,oxygen saturation,anesthetic effect,recovery time,and respiratory depression between the two groups were analyzed.Results The age of patients was 68.5±9.4 years,and the weight was 58.3±15.7 kg.There were no significant differences between the two groups in heart rate,blood pressure,oxygen saturation,anesthetic effect,recovery time,and respiratory depression (all P>0.05).The detection rate of hypotension in PS group was significantly higher than that of ES group (χ²=8.49,P=0.004).Conclusion Both propofol combined with sufentanil and etomidate combined with sufentanil were feasible and safe for aged patients with painless gastroscopy,but hypotension should be observed closely.