Abstract: Objective To investigate the disease burden and its impact factors in hepatic alveolar echinococcosis (HAE) patients with autologous liver transplantation (ALT).Methods Data on basic clinical and all relative costs were collected among 51 patients receiving ALT surgery for HAE treatment in a tertiary teaching hospital in Xinjiang Uygur Autonomous Region during August 2010 to February 2017.Both direct and indirect economic burden were calculated;then influencing factors of the disease burden were analyzed using univariate logistic regression.Results The average total economic burden for the HAE patients with ALT was 447 128.89 RMB Yuan,including direct economic burden (257 943.45 Yuan,57.54% of the total cost) and indirect economic burden (189 834.06 Yuan,42.46%).Days of hospitalization,age,and occupation are influencing factors of direct economic burden for the HAE patients.Conclusion The results of this study indicated that the direct cost accounts a major part of the disease burden for HAE patients with ALT,suggesting that the economic burden of the patients needs to be alleviated through improving medical security and financial supports.