Subacute toxicity of American ginseng lyophilized powder
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摘要: 目的 探讨西洋参冻干粉对SD大鼠的亚急性毒性。方法 将80只SPF级大鼠随机分为高、中、低西洋参组(3.00、1.50和0.75 g/kg)和对照组,对照组喂养基础饲料,西洋参组喂饲参有相应比例西洋参的基础饲料,连续喂养30 d;观察大鼠摄食量、体重增重、主要脏器的脏体比、食物利用率变化,采用血细胞分析仪、生化分析仪检测大鼠血常规、血清生化学指标,主要脏器进行病理学观察。结果 对照组及各剂量西洋参组大鼠生长发育状况良好、无死亡,精神状态与活动状况未见异常;与对照组比较,各剂量西洋参组大鼠摄食量、体重增长、食物利用率、脏体比无明显变化,血常规、血液生化等指标无明显差异;对照组及高剂量西洋参组大鼠肝、肾、脾、睾丸、卵巢等主要脏器未见明显病理改变。 结论 西洋参冻干粉对大鼠无明显亚急性毒性。Abstract: Objective To investigate the subacute toxicity of American ginseng lyophilized powder to Sprague-Dawley (SD) rats.Methods Eighty specific pathogen free (SPF) rats were randomly divided into three groups:high,moderate and low dose American ginseng groups (3.00,1.50 and 0.75 g/kg) and a control group.The control group were fed with basal feed and the American ginseng groups fed with the feed mixed by various contents of American ginseng for 30 days.Food intake,weight gain,viscera ratio of the main organs,and the change of food utilization rate of the rats were observed.The rats' routine blood indexes and serum biochemical indicators were detected using blood cell analyzer and biochemical analyzer.Pathological examinations were conducted for main organs of the rats.Results There were no abnormalities in the growth and development of the rats of control group and American ginseng groups;no death and abnormal statuses of mental and physical activity were observed in all the rats.Compared with those of the control group,the rats of American ginseng groups showed no significant differences in body weight gain,food utilization,and functions of main organs.There were no obvious pathological changes in the liver,kidney,spleen,testis or ovary of in the rats of the control group and the high dose American ginseng group.Conclusion American ginseng lyophilized powder is of no significant subacute toxicity to rats.
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Key words:
- American ginseng /
- subacute toxicity /
- serum biochemistry
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