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曲巍, 孙秀发, 付元华, 郭军旗, 刘烈刚, 郝丽萍, 毛丽梅, 杨年红. 过量酒精摄入对大鼠细胞因子及胰岛的影响[J]. 中国公共卫生, 2004, 20(10): 1174-1175.
引用本文: 曲巍, 孙秀发, 付元华, 郭军旗, 刘烈刚, 郝丽萍, 毛丽梅, 杨年红. 过量酒精摄入对大鼠细胞因子及胰岛的影响[J]. 中国公共卫生, 2004, 20(10): 1174-1175.
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QU Wei, SUN Xiu-fa, FU Yuan-hua, . IL-1β、TNF-α and IL-6 caused by chronic alcohol administration on pancreaticislets of rats[J]. Chinese Journal of Public Health, 2004, 20(10): 1174-1175.
Citation: QU Wei, SUN Xiu-fa, FU Yuan-hua, . IL-1β、TNF-α and IL-6 caused by chronic alcohol administration on pancreaticislets of rats[J]. Chinese Journal of Public Health, 2004, 20(10): 1174-1175.
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过量酒精摄入对大鼠细胞因子及胰岛的影响

IL-1β、TNF-α and IL-6 caused by chronic alcohol administration on pancreaticislets of rats

    摘要
  • 摘要:
      目的   研究长期酒精摄入对大鼠胰岛功能的影响, 以及白细胞介素Iβ(IL-1β)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)在其中的作用。
      方法   清洁级Wistar大鼠80只(雌雄各半)给予不同浓度的酒精溶液(10%, 30%, 50%)灌胃。于实验第13周末, 断头处死大鼠, 分离血清和胰腺分别检测血清中血糖、胰岛素、IL-1β、TNF-α和IL-6以及胰腺组织中IL-1β、TNF-α和IL-6水平。
      结果   50%酒精雌雄大鼠组血清胰岛素水平降低, 空腹血糖升高, 血清IL-1β、TNF-α、IL-6水平升高, 与正常对照组相比均有显著性差异(P < 0.05);胰腺组织中, 50%酒精雌性大鼠组IL-1β、TNF-α、IL-6和雄性大鼠IL-1β、TNF-α水平升高。雄性大鼠IL-6在各组间无显著性差异。
      结论   IL-1β、TNF-α、IL-6可能参与了长期过量酒精摄入而引起的胰岛β细胞功能障碍。长期过量饮酒有可能与糖尿病发生相关。

     

    Abstract:
      Objective   To investigate the effects of interleukin-1 beta(IL-1β), tumor necrosis factor-alpha(TNFA)and interleukin-6(IL-6)induced by chronic alcohol administration on pancreatic islets in rats.
      Methods   Rats were given alcohol solution(6 mg/kg·d)in different concentrations(10%, 30% and 50%)through intragastric-feeding for 13 weeks.The serum glucose, insulin and the level of IL-1β, TNF-α and IL-6 were deter mined at the end of the study.
      Results   Compared with the control group, serum glucose in 50% alcohol feeding, was increased and insulin was decreased(P < 0.05).The level of serum IL-1β, TNF-α and IL-6 were higher(P < 0.05).Chronic alcohol consumption also elevated the level of IL-1β, TNF-α and IL-6 in pancreas of female rats and the level of IL-1β and TNF-α in pancreas of male rats(P < 0.05).The cont ent of IL-6 in pancreas had no differences in the four groups of male rats(P > 0.05).
      Conclusion   Chronic alcohol intake can impair insulin secretion function of beta cells.Moreover, chronic alcohol intake can up-regulate the production of cytokines(IL-1β, TNF-α and IL-6).In a word, chornic alcohol intoxication may have effect on beta cells through cytokines.

     

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