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董庆鸣, 何忠平, 庄辉, 宋淑静, 张剑平, 刘顺爱, 姚均, 刘志英, 冯鑫, 戴旺苏. 19例SARS死亡病例免疫学特征分析[J]. 中国公共卫生, 2004, 20(1): 1-2.
引用本文: 董庆鸣, 何忠平, 庄辉, 宋淑静, 张剑平, 刘顺爱, 姚均, 刘志英, 冯鑫, 戴旺苏. 19例SARS死亡病例免疫学特征分析[J]. 中国公共卫生, 2004, 20(1): 1-2.
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DONG Qing-ming, HE Zhong-ping, ZHUANG Hui, . Immunological characiteristics of 19 death cases from severe acute respiratory syndrome[J]. Chinese Journal of Public Health, 2004, 20(1): 1-2.
Citation: DONG Qing-ming, HE Zhong-ping, ZHUANG Hui, . Immunological characiteristics of 19 death cases from severe acute respiratory syndrome[J]. Chinese Journal of Public Health, 2004, 20(1): 1-2.
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19例SARS死亡病例免疫学特征分析

Immunological characiteristics of 19 death cases from severe acute respiratory syndrome

    摘要
  • 摘要:
      目的   总结19例严重急性呼吸综合征(SARS)死亡病例的免疫学特点.
      方法   分析SARS死亡病例的一般临床特征, 并用流式细胞仪检测T淋巴细胞及其亚群、NK和B细胞绝对计数, 并与艾滋病(AIDS)患者及正常对照组比较.
      结果   SARS死亡病例的淋巴细胞总数、T、T4和T8淋巴细胞绝对数均显著低于AIDS组及正常对照组(P < 0.001), 4项指标最低值分别为85个/mm3、38个/mm3、26个/mm3和14个/mm3; SARS组的T4/T8淋巴细胞比值高于AIDS组(P < 0.001), 与正常对照组无显著性差异(P=0.8663);NK和B淋巴细胞低于正常组(P < 0.001), 最低值分别为2个/mm3和17个/mm3.
      结论   SARS患者的细胞和体液免疫功能明显低下.检测T淋巴细胞及其亚群、NK和B细胞绝对数有助于判断SARS患者的病情和预后, 并对发病早期的辅助诊断有一定意义.

     

    Abstract:
      Objective   To summarize the immunological characteristics of death cases from severe acute respiratory syndrome(SARS).
      Methods   the basic clinical characteristics of SARS death cases were analyzed.At the same time, the absolute numbers of Tlymphocyte and its subgroups, NK and B cells of 37 serum samples from 19 SARS cases were counted with the flow cytometry and compared with the normal control and the HIV groups.
      Results   the absolute numbers of lymphocytes, T, T4 and T8 lymphocytes decreased significantly(P < 0.001), as compared with those of the HIV and the normal control groups.The minimum values of the four items were 85, 38, 26 and 14 cells/mm3, respectively.The ratio of T4 to T8 lymphocytes of the SARS group was hig her than that of the HIV group(P < 0.001).There was no significant difference between SARS patients and normal controls.The NK and B cells of the SARS group declined significantly, with the minimum counts of 2 and 17 cells/mm3, respectively.
      Conclusion   the function of humoral and cellular immunity of SARS death cases was significantly low.The detection of absolute counts of Tlymphocytes and its subgroup, B and NK cells were useful for the judgement of severity and prognosis of the disease.It may be used as a supplementary diagnosis method in the early stage of SARS.

     

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