马齿苋总黄酮对人红细胞膜封闭能力的影响

Effect of portulaca total flavone on erythrocyte ghost blocking degree

摘要:
目的建立超氧阴离子自由基(O₂^-)引发人红细胞膜氧化损伤实验模型, 研究马齿苋总黄酮对红细胞膜重封闭能力的影响.
方法以邻苯三酚在碱性条件下自氧化产生(O₂^-)引发人红细胞膜氧化损伤, 并以此为实验模型研究马齿苋总黄酮对红细胞膜封闭能力的影响.
结果 O₂^-能引起红细胞膜重封闭能力显著降低, 其平均封闭度为419%, 而预先加入不同浓度的马齿苋总黄酮后能显著增加膜封闭能力, 且存在明显的剂量效应关系.
结论马齿苋总黄酮对红细胞膜封闭能力具有保护作用.

Abstract:
Objective To establish a model of oxidative damage in erythrocycte ghost induced by superoxide anion free radicals(SAFR), and to study the influence of portulaca total flavone on erythrocyte ghost blocking degree.
Methods the erythrocyte ghost oxidative damage was induced by SAFR which was produced by auto-oxidation of pyrogallicacid.The effect of portulaca total flavone on erythrocyte ghost blocking degree was studied.
Results SAFR can apparently alleviated blocking degree.But portulaca total flvone improved the membrance blocking degree significantly, and there was dose-effect relationship.
Conclusion Portulaca total flavone had certain protective action for erythrocyte ghost blocking degree.