沙漠负重行军者热休克蛋白与一氧化氮的关系

刘兵; 石胜刚; 吴志豪; 徐文; 张雪玲

沙漠负重行军者热休克蛋白与一氧化氮的关系

Relation between heat shock proteins and nitric oxide in marchers with load in desert

摘要

摘要:
目的探讨沙漠干热环境负重应激行军者热休克蛋白(HSPs)与机体一氧化氮(NO)及其一氧化氮合成酶(NOS)的关系.
方法对在沙漠干热环境中15kg负重、分别以3.5km/h和50km/h速度行军1, 2, 3h的57名战士和14名对照血浆HSP70和HSP27、NOS和NOS等进行研究.
结果在15kg负重条件下, 不管是3.5km/h还是50km/h, 各行军组HSP70与对照组及各行军时间组间HSP70均无显著性差异(P > 0.05);各行军时间组HSP27明显高于对照组(P < 0.05), 各行军时间组间HSP27无显著性差异(P > 0.05);各行军时间组NO明显低于对照组(P < 0.05).3.5km/h行军3h组NO明显低于行军1, 2h组(P < 0.05);3.5km/h行军1h组NOS明显高于对照和行军3h组(P < 0.05);50km/h行军2h组NOS明显低于对照和其它行军时间组(P < 0.05).
结论沙漠干热环境应激负重行军者血浆HSP27与NO及其NOS密切相关, HSP70与NO及其NOS关系不大.

Abstract:
Objective To explore the relation between heat shock proteins(HSP70 and HSP27)and nitric oxide(NO) and nitric oxide synthase(NOS)in marchers in dry-heat desert.
Methods the plasma HPS70, HSP27, NO and NOS of 57 marchers at different speed of different time with 15 kg and of 14 controls were detected.
Results With 15 kg at both 3.5 and 5.0km/h, the plasma HSP27 in the marching groups were much more than the control(P < 0.05);the plasma HPS70 in the marching groups were slightly more than the control(P > 0.05);and the plasma NO in the marching groups were much lower than the control.NO for 1 hour was much more than the other marching groups at 3.5km/h.As for NOS, NOS for 1 hour was much more than the control and the other groups at 3.5km/h; and NOS for 2 hour was much lower than the control and the other groups at 5.0km/h.
Conclusion In the case of loading, there was a close relation between HSP27 and NO, NOS and no relation between HSP70 and NO and NOS in marchers in dry-heat desert.

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