高级检索
廖玫珍, 姜宝法, 徐传辉, 李发贵. ApoE基因多态性与多因素作用致冠心病研究[J]. 中国公共卫生, 2004, 20(1): 55-56.
引用本文: 廖玫珍, 姜宝法, 徐传辉, 李发贵. ApoE基因多态性与多因素作用致冠心病研究[J]. 中国公共卫生, 2004, 20(1): 55-56.
shu
LIAO Mei-zhen, JIA NG Bao-fa, XU Chuan-hui, . Study on interaction between apolipoprotein E polymorphism and enviro nmental factors for coronary heart disease[J]. Chinese Journal of Public Health, 2004, 20(1): 55-56.
Citation: LIAO Mei-zhen, JIA NG Bao-fa, XU Chuan-hui, . Study on interaction between apolipoprotein E polymorphism and enviro nmental factors for coronary heart disease[J]. Chinese Journal of Public Health, 2004, 20(1): 55-56.
shu

ApoE基因多态性与多因素作用致冠心病研究

Study on interaction between apolipoprotein E polymorphism and enviro nmental factors for coronary heart disease

    摘要
  • 摘要:
      目的   探讨冠心病的主要危险因素及载脂蛋白E(ApoE)基因多态性与其它各危险因素之间的交互效应.
      方法   选择90例冠心病患者(CHD组)及90例非冠心病患者(对照组), 在Logistic回归分析的基础上, 分析各因素的比值比以及ApoE基因多态性与其它危险因素之间的交互作用.
      结果   多因素Logistic回归结果显示, 高血压史、高血脂史、肺炎衣原体(Cpn)感染、巨细胞病毒(CMV)感染和ApoE基因多态性为冠心病的危险因素, 比值比OR分别为5.04, 3.64, 2.37, 3.51, 3.33.ApoE基因多态性与高血压史、高血脂史、Cpn感染、CMV感染间交互作用指数分别为1.73, 1.55, 1.28, 1.20, 归因交互百分比分别为40.64%, 33.25%, 19.01%和15.15%.
      结论   高血压史、高血脂史、Cpn感染、CMV感染和ApoE基因多态性可能是冠心病的主要危险因素, 且ApoE基因多态性与其它危险因素在致冠心病的关系中存在正交互作用.

     

    Abstract:
      Objective   To explore the risk fators of coronary heart disease and the interactive effects between ApoE polymorphism and the other risk factors.
      Methods   90 patients with CHD and 90 control subjects without symptoms and sign of CHD was studied, on the base of logistic regression, odds ratios(OR)and interactions between ApoE polymorphism and other risk factors of coronary heart disease were analyzed.
      Results   the results of multivariable logistic regression showed thathy-pertension, hyperlipemia, Cpn infection, CMV infection and ApoE polymorphism were risk factors of coronary heart disease, odds ratios of the risk factors in coronary heart disease were 5.04, 3.64, 2.37, 3.51 and 3.33 respectively.The interaction indexs were 1173, 1155, 1128 and 1120.The attributable proportions were 40.64%, 33.25%, 19.01% and 15.15%.
      Conclusion   Hypertension, hyperlipemia, Cpn infection, CMV infection and ApoE polymorphism played important roles in the development of coronary heart disease, and ApoE plused any one of the following factors, such as hypertension, hyperlipemia, Cpninfection, CMV infection, which could increase the risk of coronary heart disease.

     

    • HTML全文
    • 参考文献(8)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回