大豆异黄酮对高脂去卵巢大鼠肝脏脂质的影响

肖本熙; 周光宇; 凌艺辉; 黄忆明

大豆异黄酮对高脂去卵巢大鼠肝脏脂质的影响

Effects of soybean isoflavone on liver lipids of ovariectony rats with high fat diet

摘要

摘要:
目的观察大豆异黄酮(SI)对进食高脂饲料的去卵巢大鼠脂质和肝组织过氧化状态的影响.
方法 50只SD大鼠随机分为5组, 分别接受假手术+基础饲料; 去卵巢+高脂饲料; 去卵巢+高脂饲料+SI3个剂量组20, 60, 180mg/(kg·bw·d)处理, 实验期8周.
结果与模型组比较, SI可显著抑制高脂饲料所致的去卵巢大鼠肝脏和血清甘油三酯水平升高(P < 0.05), 但对肝脏总胆固醇变化无影响(P > 0.05).与假手术组和模型组比较, SI降低肝脏MDA含量均有显著性差异(P < 0.01).
结论 SI对去卵巢大鼠肝脏高甘油三酯有降低作用, 并能改善高脂饮食所致的肝脏过氧化状态异常, 减轻对机体的过氧化损伤.

Abstract:
Objective To study the effects of soybean isoflavone(SI)on lipid's metabolism and lipid peroxidation in the liver of ovariectony rats fed with high fat diet.
Methods 50 SD rats were randomly divided into 5 groups: sham ovariectony and normal diet control; ovariectony and high fat diet control; ovariectony and high fat diet with three concentrations of SI supplied 120, 60, 180 mg/(kg·bw·d) groups.The duration of exposure was 8 weeks.
Results Compared with the OVX group, SI can significantly decrease the concentration of triglyceride in both serum and liver of the hyperlipidemic rats(P < 0.05), but there was no effect on the contents of total cholesterol in the liver(P > 0.05).Compared with the normal and OVX groups, SI can significantly decrease the concentration of MDA of the liver tissue as well(P < 0.01).
Conclusion SI can decrease the level of hypertrigly ceride in the liver of the ovariectony rats and it can also decrease the peroxidative damage of the liver by means of ameliorating the abnormal peroxidative state in liver.

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