高级检索
胡晓抒, 郭志荣, 喻荣彬, 张均, 孙国祥, 周正元, 周静, 姚才良. 高血压与多代谢异常的病例对照研究[J]. 中国公共卫生, 2003, 19(11): 1315-1317.
引用本文: 胡晓抒, 郭志荣, 喻荣彬, 张均, 孙国祥, 周正元, 周静, 姚才良. 高血压与多代谢异常的病例对照研究[J]. 中国公共卫生, 2003, 19(11): 1315-1317.
HU Xiao-shu, GOU Zhi-rong, YU Rong-bin, . Case-control study on hypertension and multiple metabolic disorders[J]. Chinese Journal of Public Health, 2003, 19(11): 1315-1317.
Citation: HU Xiao-shu, GOU Zhi-rong, YU Rong-bin, . Case-control study on hypertension and multiple metabolic disorders[J]. Chinese Journal of Public Health, 2003, 19(11): 1315-1317.

高血压与多代谢异常的病例对照研究

Case-control study on hypertension and multiple metabolic disorders

  • 摘要:
      目的   探索高血压与多代谢异常的关系.
      方法   以中国心血管健康多中心合作研究中苏南经济发达地区城市和农村两社区人群, 448例原发性高血压病人和1120例对照进行合并多代谢异常情况病例对照研究.
      结果   不论男女, 高血压患者的各类代谢异常比例均明显高于对照组; 高血压组79.69%、对照组58.44%合并1种以上代谢异常, 高血压组合并3种代谢异常的aOR为7.13(95%CI: 4.16~11.50);合并超重/肥胖、糖尿病的aOR为13.26(95%CI: 5.25~34.48);其他合并2种代谢异常的aOR在2.0~5.0的范围, 但单纯合并糖尿病似乎并不常见, aOR=1.36(95%CI: 0.56~3.27).吸烟、饮酒、体力活动等行为因素对高血压合并多代谢异常并未产生明显影响, 但过去和现在吸烟、工作之余从事体育活动者比例明显高于对照者; 此外高血压家族史对多代谢异常有一定影响.
      结论   80%高血压患者合并1种以上代谢异常, 30%合并2种及2种以上代谢异常; 与高血压合并的代谢异常中, 超重/肥胖和糖尿病可能更容易聚集.因此, 对高血压或者诸多代谢紊乱在高血压患者中聚集的控制、减重或综合生活方式干预至少和控制血压同样重要.

     

    Abstract:
      Objective   To explore the relationship between hypertension and multiple metabolic disorders.
      Methods   Based on the two community populations in south Jiangsu province from Chinese multicenter cardiovascular health cooperative project, a case-control study was conducted including 448 cases of essential hypertension and 1 120 controlled patients.
      Results   Various metabolic syndromes were higher in cases than in controls, regardless in both male and female subjects.Among cases, 79.69% of them had at least one more metabolic abnormalities as compared 58.44% in controls.The adjusted odds ratio (aOR)of cases who had 3 metabolic syndromes was 7.13, with 95%CI: 4.16-11.50.The a OR of cases with other abnormal metabolic syndrome ranged 2.0-5.0.However, there was no significant difference in complicated diabetes between the cases and the controls, a OR=1.36(95%CI: 0.56-3.27).The occurrence of multile metabolic syndromes in hypertensive patient was associated with certain behavior factors(smoking, alcohol, physical activities).Howerver, the proportions of post and current smoking and physical activities at leisure time were significantly higher in the cases than in the controls.In addition, family history of hypertension was associated with occurrence of multiple metabolic syndromes in patients with hypertension.
      Conclusion   Among hypertensive patients, 80% of them complicated with at least one metabolic syndrome, 30% with two and more metabolic abnormalities.Overweight/obese and diabetes were the commonest metabolic syndromes.In order to reduce metabolic disorders in hypertensive patients, multiple lifestyle behavior interventions such as losing weight were as important as blood pressure control.

     

/

返回文章
返回