大蒜素对顺铂所致大鼠肾损害的预防作用

刘勇; 仲来福

大蒜素对顺铂所致大鼠肾损害的预防作用

刘勇,
仲来福

Preventive effects of allitridi on cisplatin-induced nephrotoxicity in rats

摘要

摘要:
目的研究大蒜素对顺铂(CDDP)所致肾损害的预防作用及其可能机制.
方法将SD大鼠按体重随机分3组, 分别为对照组(生理盐水组)、CDDP组、CDDP+大蒜素组.处理后, 分别在1, 3, 5d测体重、肾脏系数、血清尿素氮(BUN)、肾皮质匀浆丙二醛(MDA)以及超氧化物歧化酶(SOD)活性等.
结果大蒜素预处理可减轻CDDP引起的体重降低、肾脏系数升高及BUN水平升高; 能抑制CDDP引起的MDA形成增高; 并能抑制CDDP引起的SOD活性下降.
结论大蒜素经口给予能预防CDDP所致的肾损害, 其机制可能与其强大的抗氧化和清除自由基活性有密切关系.

Abstract:
Objective To study the effects of allitridi on cisplatin(CDDP)-induced nephrotoxicity and exploreits possible mechanisms in rats.
Methods Male Sprague-Dawley rats were randomly divided into three groups: control, CDDP, CDDP+allitridi.Then rats were killed on day 1, 3, 5 after CDDP treatment.Nephrotoxicity was assessed by measurements of body weight, kidney index, the contents of blood ureanitrogen(BUN), changes in malondialdehyde(MDA)formation and the activity of superoxide dismutase(SOD)in kidney cortexhomogenate.
Results Allitridi pretreatment would alleviate the CODP-induced changes of body weight, kidney index, BUN, and inhibit the increases of MDA formation in kidney cortex homogenate, and enhance the decrease of activities of SOD in kidney cortex homogenate in rats.
Conclusion By oral administration, allitridi pr etreatment can remarkably alleviate CDDP-induced nephro to xicity.The mechanisms may be involved in antioxidation, scanvaging of free radicals, and enhancement of the activities of some antioxidant enzymes.

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