HIV感染者CD4/CD8细胞与病毒载量的关系
Relationship between CD4/CD8 cell levels and plasma viral load in HIV-infected people
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摘要:目的 探讨HIV感染者体内CD4细胞数与病毒载量的关系.方法 对84人的207次血样进行病毒载量的测定, 对194人的491次血样进行CD4/CD8细胞数的检测.CD4/CD8细胞计数采用流式细胞仪的绝对计数法进行检测, 使用核酸序列测试(NASBA)方法检测病毒载量.对其中一部分人进行随访, 采集血样并检测相应指标.结果 HIV感染者体内的CD4细胞数与病毒载量的Log值呈负相关(r=-0.576, P < 0.01), CD4/CD8比值与病毒载量的Log值呈负相关(r=-0.544, P < 0.01).CD4细胞数较低的感染者, CD8细胞数也较低.在HIV感染者体内, 随着病毒载量的升高, CD4细胞数呈下降趋势.结论 病毒载量与CD4有明显的相关关系, 当病毒载量较低时, 使用CD4细胞数可以粗略估计血浆中病毒载量的高低.CD4/CD8比值与病毒载量的Log值呈现负相关.当病毒载量较高时, HIV感染者体内病毒载量与CD4细胞数的变化趋势相反, 但不完全同步.Abstract:Objective To investigate the relationship between the CD4/CD8 cell levels and the plasma viral load in HIV -infected people.Methods The viral load of 207 blood samples of 84 cases were tested.The CD4/CD8 cell levels of 491 blood samples of 194 cases were tested.11 of HIV-infected cases were followed up at regular intervals and their viral load and CD4/CD8 cell levels were tested.The data were analyzed statistically using SPSS software to explore the trend and correlations.Results There are significantly negative correlation trend between the CD4 cell levels and viral load(r=-0.576, P < 0.01).Close correlation were observed between the CD4/CD8 ratio and the viral load(r=-0.544, P < 0.01).The CD8 cell levels were also low in the cases with low CD4 cell levels.With the lossing of CD4 cells, the CD8 cell levels would descend.Conclusion The CD4 cell levels and the ratios of CD4/CD8 were useful indicators to viral load.In the cases with low CD4 cell levels, the changing trends of the CD4 cell levels and viral load were reverse, but not synchronous.
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