Abstract:
Objective To understand effects of MeHg on DNA damage and repair in lymphocytes of blood and thymus of mice.
Methods Unscheduled DNA synthesis was used in vitro.
Results MeHg could make UDS increase in some range.There were significant differences between 1.00 mmol/L blood lymphocyte and 5.00mmol/L lymocyte compared with the control group(P < 0.05).The UDS of the low doses and the high doses gruops was decreased compared with that of the control group.
Conclusion MeHg could caused the lymphocytes DNA damage in the blood and thymus, and MeHg had genetic and immune toxicities.