乙型肝炎重叠HGV感染的研究

苏洁寒; 谢志春; 覃锦耀

乙型肝炎重叠HGV感染的研究

Study on Hepatitis B with Hepatitis G virus superinfection

摘要

摘要:
目的探讨乙型肝炎重叠庚型肝炎病毒(HGV)感染的状况及庚型肝炎病毒对乙肝患者的影响。
方法采用逆转录聚合酶链反应(RT-PCR)检测165例乙肝患者和160例健康人血清中的HGV-RNA及检测乙肝重叠HGV感染患者及单纯乙肝患者的抗HBc-IgM、HBV-DNA、HBeAg, 比较其临床症状和体征的差异。结果HGV在乙肝患者的感染率为14.5%, 高于健康人感染率19%(P < 0.001);HGV在各型乙肝及肝硬化患者中的阳性率相似(P > 0.05);乙肝重叠HGV感染者及单纯乙肝患者病毒复制指标抗-HBc-IgM, HBV-DNA, HBeAg以及肝功能, 临床症状及体征比较无显着性差异(P > 0.05)。
结论 HGV在乙肝患者中的感染率比健康人高; HGV对HBV的复制无影响, 并且HGV不会加重乙肝患者肝脏损害和临床症状; 并可推测HGV对乙型肝炎和肝硬化的发展无促进作用。

Abstract:
Objective To investigate the infective state of hepatitis B patients who superinfected with HGV and the effect of HGV on hepatitis B patients.
Methods Reverse transcription polymerase chain reaction technique(RT-PCR)was used to determine HGV-RNA in the serum of 165 hepatitis patients and 160 healthy persons; HBc-IgM、HBV-DNA and HBeAg were measured and the difference of clinical symptoms and signs were compared between hepatitis B superinfectecd with HGV and patients with hepatitis B alone.
Results The infection rate of HGV in heptitis Bpatients was 14.5%, which was higher than that of 1.9% in healthy population(P < 0.001).There were no significant differences in antiHBc-IgM, HBV-DNA, HBeAg and liver function as well as clinical symptoms and signs between hepatitis B patients superinfected with HGV and patients with hepatitis B alone(P > 0.05).
Conclusion The infection rate of HGV in hepatitis B patients was higher than that in healthy population; HGV had no effect on the replication of HBV, which did not aggravate liver injury and clinical symptoms in hepatitis Bpatients.HGVdid not accelerate the development of hepatitis Band cirrhosis.

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