肾综合征出血热与HLA-DR基因多态性的关联

Association between epidemic hemorrhagic fever and HLA-DR alle polymorphish

摘要:
目的探讨人类主要组织相容性复合体-DR(HLADR)基因多态性与肾综合征出血热(HFRS)之间的关联性。
方法采用聚合酶链反应-序列特异性引物(PCRSSP)DNA分型技术对遵义地区汉族39例HFRS患者和28例健康对照进行HLADR基因分型。
结果 HLADRB3 ^*基因频率在HFRS患者组较正常对照组明显增高(RR=5.04, χ ²=9.988, P < 0.01);HLADRB1 ^*09012基因频率较正常对照组明显降低(RR=0.24, χ ²=7.216, P < 0.01);其它等位基因频率在患者组与对照组间无显着性差异。
结论在遵义地区汉族人群中, 肾综合征出血热可能与HLADRB3 ^*基因呈正相关, 与HLADRB1 ^*09012基因呈负相关。

Abstract:
Objective To explore the association between epidemic hemorrhagic fever(HFRS)and HL A-DRalle polymorphish.
Methods Twenty-eight normal people and 39 HFRS patients of Han nationality in Zunyi were tested for HLA-DR by poly merase chain reaction with sequence specific primers(PCR-SSP).
Results HLA-DRB3 ^* gene frequencies with HFRS was markedly higher in patients than in controls(RR=5.04, χ ²=9.988, P < 0.01);HLA-DRB1 ^*09012 gene frequencies significantly lower in patients(RR=0.24, χ ²=7.216, P < 0.01);while the frequencies of other DR alleles were not significantly increased in patients.
Conclusion HFRS be positive related to HLA-DRB3 ^* and was negatively related to HLA-DRB1 ^*09012.