老龄男性血清PSA检测与组织病理免疫组化研究

Study on serum PSA determination and tissues pathology immunohis tochemistry

摘要:
目的以一汽集团526名50岁以上男性在职与离退休职工为受检对象, 另以101名20~39岁年轻人和16名40~49岁者为对照, 研究前列腺特异性抗原(PSA)与前列腺疾病的关系。
方法通过血清前列腺肿瘤标志物-PSA含量测定, 对血清PSA含量 > 4.0ng/ml者与血清PSA含量正常, 但前列腺体积明显增大伴有排尿困难者, 采用经会阴四点穿刺取活体组织做病理与免疫组织化学分析。
结果血清PSA含量 > 4.0ng/ml者占15.09%.对活检的40例病理标本检查发现, 前列腺增生占81.08%.前列腺癌的检出率为0.95%。
结论 50岁以上人群Ⅱ度、Ⅲ度前列腺增生发现率 > 60%.前列腺癌的发现率约1%。

Abstract:
Objective The treatise reported the PSA levels in the sera of 526 asymptomatic men(over 50 years old), 16 men(age between 40-49)and 101 men(younger than 40years, control group)were determined.
Methods Ninety-three men whose serum PSAlevels were highere than 4.0 ng/ml were selected for biopsy.Tissues pathology analysis as well as PSA expression of prostatic tissues derived from biopsy were analyzed by methods of immuno histochemistry in biopsied men.
Results Prostatic hyperplasia was 81.08% in 40 case sample, prostatic cancer was 0.95%.
Conclusions The incidence rates of analysis benign prostatic hyperplasia was more than 60% and that of prostatic cancer was about 1% in men over 50 years old.