Abstract:
Studtes were carried out to compare the therapeutic effects of "751" (ethyl4(5)-imidazoleearboxylate) and penieillin against leptospira infection in golden hamsters. The treatment was started 24 hr or 48 hr after challenge with 100 or 1000 LO
60 of highly virulent Leptospira icterohae morrhagiae and the animals were observed for 14 days thereafter. The dosages of the drugs were the lowest dose usually used in clinical treatment of leptosp-irosis and 2 times or 3 times of that dose. In another exPeriment,animals were challenged with 100LO
50 of leptosipra 48 hr after intraperitoneal injection of cyclophospilamide and treated with 3 times the lowest clinical dose.