乙型肝炎病毒子宫内传播的存在

Evidence for Intrauterine Transmission of Hepatitis B Virus

摘要: 在乙型肝炎高流行区，母婴传播是乙型肝炎病毒(HBV)的重要传播方式。HBV母婴传播一般被认为有三条途径：①子宫内传播；②分娩期传播和③产后传播，迄今仅有一些间接的依据提示HBV子宫内传播的可能性。

Abstract: Sixteen fetuses from 16 HBsAg-positive mothers were examined for HBV markers and HBsAg particles were found in the serum samples and liver homogenates of 7 fetuses by immunoelectron microscopy. HBsAg and HBcAg were found in the bepatocytes by PAP method and HBsAg was detected is the cytoplasm of hepatocytes of 4 fectuses, in one of which HBcAg was observed at the perinuclear area of the hepatocytes. From the above-mentioned results, it was demonstrated by immunoelectron microscopy and immunobistochemistry that HBV could be transmitted from HBsAg carrier mothers to their fetal offspring,the hepatocyes of which could be infected by the replicating HBV.