利用淋巴细胞非程序DNA损伤/修复试验探讨人肺组织中苯并(a)芘的代谢活化
Investigation on Metabolic Activation of Benzoapyrene in Human Lung Tissue by the Test for Unschedu led DNA syntnesis in Lymphocytes
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摘要: 苯并(a)芘(BP)是一种在环境中广泛存在的致癌污染物。目前已经证明，BP进入细胞后需要经过芳烃羟化酶(AHH)和环氧化物水化酶(EH)代谢方可发挥致癌作用。肺脏是大气中污染物进入机体的主要门户，是BP发挥致癌作用的靶器官。Abstract: By the test for Unschedu led DNA syatnesis in lymphocytes, the ability of metabolic activation of benzo(a)pyrene (BP) is human lung tissue was studied.The results showed that the effect on the damage of DNA induced through metabolic activation of BP is lung tissue of patients with lung cancer was higher than that of patients without such cancer (0.05
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